国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Discordance of Apolipoprotein B with Low-Density Lipoprotein Cholesterol or Non-High Density Lipoprotein cholesterol and Coronary Atherosclerosis

第一作者：Xin Su,Xueli Cai

通讯作者：Yan He,Tieming Wei

Apolipoproteins Coronary atherosclerosis plaques Discordance analysis Lipoproteins

基本信息

2022-09-27

已发表文章

发表杂志：European Journal of Preventive Cardiology

发表类型: Original Research Article

影响因子(IF): 8.526

PMID: 36166398 Pubmed原文链接 全文下载

主要研究背景及目的

High level of apolipoprotein B (Apo B) is associated with incident coronary artery disease (CAD) when low-density lipoprotein cholesterol (LDL-C) level or non–high density lipoprotein cholesterol (non–HDL-C) is low. However, data on the relationship of Apo B with coronary atherosclerosis plaques burden are limited. The present study aimed to estimate associations between Apo B with the presence and burden of coronary atherosclerosis plaques.

方法

Multivariate binary logistic regression and multivariate ordinal logistic regression. Discordance analysis defining based on residuals and medians.

结论

Discordantly high Apo B with LDL-C and non-HDL-C were associated with an increased odds of the coronary atherosclerotic plaques and its burden. These findings highlighted the importance of Apo B for primary prevention of coronary atherosclerosis.

主要结果