Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Effects of genetically determined mineral status on life expectancy: a Mendelian randomization study
First author：Hongjuan Fang
Corresponding author：Yuesong Pan
essential_information
- Person in charge：Hongjuan Fang
- Data Sources： OTHERS
- Number of papers：OTHERS20230045
- Published time：2023-01-04
2023-01-04
Published articles
Journal：Chin Med J (Engl)
Publication type: Comments and Opinions
IF(IF): 6.133
PMID: 36808119 Link To Pubmed Full text Download
Background And Purpose
Mineral supplements are usually regarded as compounds crucial to promoting overall health status and longevity. Systemic mineral status has been demonstrated to be associated with life expectancy in many observational studies, while the causal effects of mineral status on life expectancy have not yet been systematically elucidated.
Method
In this study, we investigated the causal effects of six minerals (calcium, magnesium, iron, copper, zinc, and selenium) on life expectancy with large-scale genome-wide association study (GWAS) summary data using two-sample Mendelian randomization (MR) analysis.
Conclusion
In conclusion, findings of this MR study showed that genetically higher serum calcium, serum iron, and blood zinc concentrations may be associated with a reduced life expectancy.
Main results
genetically predicted higher serum calcium, serum iron, blood zinc status appeared to have decreased the life expectancy. The association of a 1-SD increase in genetically predicted mineral status with lifespan years was –1.36 for serum calcium (95% CI: –2.57, –0.15; P = 0.027), –0.70 for serum iron (95% CI: –0.97, –0.44; P <0.001), and –0.56 for blood zinc (95% CI: –0.82, –0.30; P <0.001).