国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Effects of genetically determined mineral status on life expectancy: a Mendelian randomization study
第一作者：Hongjuan Fang
通讯作者：Yuesong Pan
基本信息
- 负责人：Hongjuan Fang
- 数据来源： OTHERS
- 论文编号：OTHERS20230045
- 发表时间：2023-01-04
2023-01-04
已发表文章
主要研究背景及目的
Mineral supplements are usually regarded as compounds crucial to promoting overall health status and longevity. Systemic mineral status has been demonstrated to be associated with life expectancy in many observational studies, while the causal effects of mineral status on life expectancy have not yet been systematically elucidated.
方法
In this study, we investigated the causal effects of six minerals (calcium, magnesium, iron, copper, zinc, and selenium) on life expectancy with large-scale genome-wide association study (GWAS) summary data using two-sample Mendelian randomization (MR) analysis.
结论
In conclusion, findings of this MR study showed that genetically higher serum calcium, serum iron, and blood zinc concentrations may be associated with a reduced life expectancy.
主要结果
genetically predicted higher serum calcium, serum iron, blood zinc status appeared to have decreased the life expectancy. The association of a 1-SD increase in genetically predicted mineral status with lifespan years was –1.36 for serum calcium (95% CI: –2.57, –0.15; P = 0.027), –0.70 for serum iron (95% CI: –0.97, –0.44; P <0.001), and –0.56 for blood zinc (95% CI: –0.82, –0.30; P <0.001).