Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
New Diffusion Abnormalities Following Endovascular Treatment for Intracranial Atherosclerosis
First author：Hou Zhikai,Jing Jing
Corresponding author：Ma Ning
essential_information
- Person in charge：Hou Zhikai,Jing Jing
- Data Sources： OTHERS
- Number of papers：OTHERS20230069
- Published time：2023-03-28
2023-03-28
Published articles
Journal：Radiology
Publication type: Original Contributions
IF(IF): 29.1
PMID: https://pubs.rsna.org/doi/10.1148/radiol.221499 Link To Pubmed Full text Download
Background And Purpose
Background: There are limited data on new ischemic brain lesions after endovascular treatment for symptomatic intracranial atherosclerotic stenosis (ICAS). Purpose: To investigate the (a) characteristics of new ischemic brain lesions at diffusion-weighted MRI (new diffusion abnormalities) after endovascular treatment, (b) characteristics between those treated with balloon angioplasty and stenting procedures, and (c) predictors of new ischemic brain lesions.
Method
Materials and Methods: Patients with symptomatic ICAS in whom maximum medical therapy failed were prospectively enrolled between April 2020 and July 2021 from a national stroke center and underwent endovascular treatment. All study participants underwent thinsection diffusion-weighted MRI (voxel size, 1.4 × 1.4 × 2 mm3 with no section gap) before and after treatment. The characteristics of new ischemic brain lesions were recorded. Multivariable logistic regression analysis was performed to determine potential predictors of new ischemic brain lesions.
Conclusion
Conclusion: New ischemic brain lesions on diffusion-weighted MRI scans were common after endovascular treatment for symptomatic intracranial atherosclerotic stenosis, and occurrence may be associated with cigarette smoking and the number of operation attempts.
Main results
Results: A total of 119 study participants (mean age, 59 years ± 11 [SD]; 81 men; 70 treated with balloon angioplasty and 49 with stent placement) were enrolled. Of the 119 participants, 77 (65%) had new ischemic brain lesions. Five of the 119 participants (4%) had symptomatic ischemic stroke. New ischemic brain lesions were located in (61%, 72 of 119) and beyond (35%, 41 of 119) the territory of the treated artery. Of the 77 participants with new ischemic brain lesions, 58 (75%) had lesions located in peripheral brain areas. There was no evidence of a difference in the incidence of new ischemic brain lesions between the balloon angioplasty and the stent groups (60% vs 71%, P = .20). In adjusted models, cigarette smoking (odds ratio [OR] 3.6; 95% CI: 1.3, 9.7) and more than one operative attempt (OR, 2.9; 95% CI: 1.2, 7.0) were independent predictors of new ischemic brain lesions.