国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

New Diffusion Abnormalities Following Endovascular Treatment for Intracranial Atherosclerosis

第一作者：Hou Zhikai,Jing Jing

通讯作者：Ma Ning

Intracranial Atherosclerosis

基本信息

2023-03-28

已发表文章

发表杂志：Radiology

发表类型: Original Contributions

影响因子(IF): 29.1

PMID: https://pubs.rsna.org/doi/10.1148/radiol.221499 Pubmed原文链接 全文下载

主要研究背景及目的

Background: There are limited data on new ischemic brain lesions after endovascular treatment for symptomatic intracranial atherosclerotic stenosis (ICAS). Purpose: To investigate the (a) characteristics of new ischemic brain lesions at diffusion-weighted MRI (new diffusion abnormalities) after endovascular treatment, (b) characteristics between those treated with balloon angioplasty and stenting procedures, and (c) predictors of new ischemic brain lesions.

方法

Materials and Methods: Patients with symptomatic ICAS in whom maximum medical therapy failed were prospectively enrolled between April 2020 and July 2021 from a national stroke center and underwent endovascular treatment. All study participants underwent thinsection diffusion-weighted MRI (voxel size, 1.4 × 1.4 × 2 mm3 with no section gap) before and after treatment. The characteristics of new ischemic brain lesions were recorded. Multivariable logistic regression analysis was performed to determine potential predictors of new ischemic brain lesions.

结论

Conclusion: New ischemic brain lesions on diffusion-weighted MRI scans were common after endovascular treatment for symptomatic intracranial atherosclerotic stenosis, and occurrence may be associated with cigarette smoking and the number of operation attempts.

主要结果

Results: A total of 119 study participants (mean age, 59 years ± 11 [SD]; 81 men; 70 treated with balloon angioplasty and 49 with stent placement) were enrolled. Of the 119 participants, 77 (65%) had new ischemic brain lesions. Five of the 119 participants (4%) had symptomatic ischemic stroke. New ischemic brain lesions were located in (61%, 72 of 119) and beyond (35%, 41 of 119) the territory of the treated artery. Of the 77 participants with new ischemic brain lesions, 58 (75%) had lesions located in peripheral brain areas. There was no evidence of a difference in the incidence of new ischemic brain lesions between the balloon angioplasty and the stent groups (60% vs 71%, P = .20). In adjusted models, cigarette smoking (odds ratio [OR] 3.6; 95% CI: 1.3, 9.7) and more than one operative attempt (OR, 2.9; 95% CI: 1.2, 7.0) were independent predictors of new ischemic brain lesions.