Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Associations of 10-year atherosclerotic cardiovascular disease risk scores with cerebral small vessel disease: the PRECISE study
First author：Dandan Liu,Yanli Zhang
Corresponding author：Yuesong Pan,Yilong Wang
essential_information
- Person in charge：Dandan Liu,Yanli Zhang
- Data Sources： PRECISE
- Number of papers：PRECISE20230097
- Published time：2024-07-02
2024-07-02
Published articles
Journal：Age ang Ageing
Publication type: Article
IF(IF): 6
PMID: 39078155 Link To Pubmed Full text Download
Background And Purpose
10-year atherosclerotic cardiovascular disease (ASCVD) risk scores were useful for predicting large vessel disease, but the relationships between them and cerebral small vessel disease (CSVD) were unclear. Our study aimed to evaluate associations of 10-year ASCVD risk scores with CSVD and its MRI markers.
Method
Community-dwelling residents from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study were included in this cross-sectional study. We collected data related to Framingham risk score (FRS), pooled cohort equation (PCE), prediction for ASCVD risk in China (China-PAR) and Systematic COronary Risk Evaluation model 2 (SCORE2), and classified participants into low, moderate and high groups based on baseline 10-year ASCVD risk scores. At baseline, participants underwent brain MRI scans. We evaluated white matter hyperintensity (WMH), lacunes, cerebral microbleeds (CMBs) and enlarged perivascular spaces in basal ganglia (BG-EPVS) according to criteria of Wardlaw and Rothwell, and calculated total CSVD score and modified total CSVD score. Associations of 10-year ASCVD scores with CSVD and MRI markers were analyzed by logistic regression models.
Conclusion
The 10-year ASCVD scores were positively associated with CSVD and its MRI markers. These scores provided a method of risk stratification in the population with CSVD.
Main results
A total of 3063 participants were included, and 53.5% of them were female. Higher FRS was associated with higher total CSVD score (moderate vs. low: cOR 1.89, 95% CI 1.53 to 2.34; high vs. low: cOR 3.23, 95%CI 2.62 to 3.97), and PCE, China-PAR or SCORE2 score was positively related to total CSVD score (P<0.05). Moreover, higher 10-year ASCVD scores were associated with higher odds of WMH (P<0.05), lacunes (P<0.05), CMBs (P<0.05) and BG-EPVS (P<0.05).