国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Associations of 10-year atherosclerotic cardiovascular disease risk scores with cerebral small vessel disease: the PRECISE study

第一作者：Dandan Liu,Yanli Zhang

通讯作者：Yuesong Pan,Yilong Wang

10-year atherosclerotic cardiovascular disease risk scores cerebral small vessel disease

基本信息

2024-07-02

已发表文章

发表杂志：Age ang Ageing

发表类型: Article

影响因子(IF): 6

PMID: 39078155 Pubmed原文链接 全文下载

主要研究背景及目的

10-year atherosclerotic cardiovascular disease (ASCVD) risk scores were useful for predicting large vessel disease, but the relationships between them and cerebral small vessel disease (CSVD) were unclear. Our study aimed to evaluate associations of 10-year ASCVD risk scores with CSVD and its MRI markers.

方法

Community-dwelling residents from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study were included in this cross-sectional study. We collected data related to Framingham risk score (FRS), pooled cohort equation (PCE), prediction for ASCVD risk in China (China-PAR) and Systematic COronary Risk Evaluation model 2 (SCORE2), and classified participants into low, moderate and high groups based on baseline 10-year ASCVD risk scores. At baseline, participants underwent brain MRI scans. We evaluated white matter hyperintensity (WMH), lacunes, cerebral microbleeds (CMBs) and enlarged perivascular spaces in basal ganglia (BG-EPVS) according to criteria of Wardlaw and Rothwell, and calculated total CSVD score and modified total CSVD score. Associations of 10-year ASCVD scores with CSVD and MRI markers were analyzed by logistic regression models.

结论

The 10-year ASCVD scores were positively associated with CSVD and its MRI markers. These scores provided a method of risk stratification in the population with CSVD.

主要结果

A total of 3063 participants were included, and 53.5% of them were female. Higher FRS was associated with higher total CSVD score (moderate vs. low: cOR 1.89, 95% CI 1.53 to 2.34; high vs. low: cOR 3.23, 95%CI 2.62 to 3.97), and PCE, China-PAR or SCORE2 score was positively related to total CSVD score (P<0.05). Moreover, higher 10-year ASCVD scores were associated with higher odds of WMH (P<0.05), lacunes (P<0.05), CMBs (P<0.05) and BG-EPVS (P<0.05).