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Elevated Atherogenic Index of Plasma Increased the Risk of Myocardial Infarction in a General Population

First author：Yijun Zhang

Corresponding author：Anxin Wang

Atherogenic index of plasma Longitudinal pattern Myocardial infarction Risk factor

essential_information

  • Person in charge：Yijun Zhang
  • Data Sources： Kailuan Study
  • Number of papers：KAILUAN STUDY20230195
  • Published time：2023-11-16

2023-11-16

Published articles

Journal：ANNALS OF EPIDEMIOLOGY

Publication type: Original Contributions

IF(IF): 5.6

PMID: 37979893 Link To Pubmed Full text Download

Background And Purpose

The atherogenic index of plasma (AIP) has been shown to be related to cardiovascular disease risk, but evidence on the longitudinal pattern of AIP during follow-up is limited. We aimed to explore the associations of baseline and long-term AIP with the risk of myocardial infarction (MI).

Method

We included 98,861 participants in the Kailuan Study who were free of MI at baseline. AIP was calculated as log (triglyceride/high-density lipoprotein cholesterol). Long-term AIP included the long-term mean AIP (mean AIP from baseline to the first occurrence of MI or the end of follow-up) and number of visits with high AIP (above the cutoff value at the first three visits). The baseline and updated mean AIP were in operationalized as quartiles. Cox proportional hazard models were used to determine the associations between AIP and risk of MI. We excluding all deaths during the follow-up visits in the sensitivity analysis.

Conclusion

Elevated levels of both baseline and long-term AIP increased the risk of MI.

Main results

During a median follow-up of 12.80 years, 1804 participants developed MI. Compared with quartile 1, the adjusted hazard ratios in baseline and updated mean AIP quartile 4 were 1.63 (95% CI, 1.41-1.88) and 1.59 (95% CI, 1.37-1.83), respectively. Compared with participants who did not have a high AIP, the HR among individuals with AIP elevated by three times was 1.94 (95% CI,1.55-2.45). The sensitivity analysis showed similar associations.