国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Colchicine for preventing stroke in patients with and without intracranial atherosclerotic stenosis: a prespecified analysis of a randomized clinical trial
第一作者：Jiejie Li,Jing Jing
通讯作者：Yongjun Wang
基本信息
- 负责人：Jiejie Li,Jing Jing
- 数据来源： CHANCE-3
- 论文编号：CHANCE-320250034
- 发表时间：2025-05-19
2025-05-19
已发表文章
主要研究背景及目的
Limited therapies are available to patients with stroke due to ICAS, who are at particularly high risk of a recurrent stroke. In the recent CHANCE-3 trial, conducted 2022–2023, the effect of colchicine on rates of early recurrent stroke differed according to age (interaction p = 0.02), raising the hypothesis that patients younger than 65 years of age may benefitfrom colchicine.
方法
Cox proportional hazards regression was performed with treatment, presence of sICAS, and the treatment by presence of sICAS interaction as covariates, to test the interaction between the differential effects of colchicine versus placebo on efficacy and safety outcomes.