Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Homocysteine and Its Relationship to Asymptomatic Carotid Stenosis in a Chinese Community Population
First author：Anxin Wang
Corresponding author：Xingquan Zhao
essential_information
- Person in charge：Anxin Wang
- Data Sources： APAC
- Number of papers：APAC20180094
- Published time：2016-11-21
2016-11-21
Published articles
Journal：Scientific Reports
Publication type: Original Contributions
IF(IF): 4.379
PMID: 27869211 Link To Pubmed Full text Download
Background And Purpose
Little is known about the association between homocysteine (Hcy) and asymptomatic CAS in the healthy population. The purpose of this study was to investigate the relationship between Hcy levels andasymptomatic CAS in a Chinese community population.
Method
The current study included 5393 participants who were age of 40 years or older, and free of stroke, transient ischemic attack, and coronary artery disease. Demographic and clinical variables were investigated, and the presence of CAS was assessed by Color Doppler Ultrasound. A multivariate logistic regression was used to examine the association between Hcy levels and asymptomatic CAS.
Conclusion
In this large-population, community-based study, Hcy is an independent indicator of asymptomatic CAS, especially in patients with diabetes.
Main results
361 (6.69%) participants were diagnosed with asymptomatic CAS, who had higher Hcy levels compared with those without (p-value for trend = 0.0001). After adjusting other possible risk factors, Hcy > 19.3μmol/L was considered as an independent indicator of asymptomatic CAS (OR 1.53, 95%CI 1.05-2.23; p-value for trend = 0.0265), but with a difference between participants with diabetes and without [OR (95%CI): 2.89(1.02-8.22) vs. 1.42(0.95-2.12); P interaction < 0.05].