国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Homocysteine and Its Relationship to Asymptomatic Carotid Stenosis in a Chinese Community Population

第一作者：Anxin Wang

通讯作者：Xingquan Zhao

Homocysteine；Asymptomatic Carotid Stenosis；Chinese

基本信息

  • 负责人：Anxin Wang
  • 数据来源： APAC
  • 论文编号：APAC20180094
  • 发表时间：2016-11-21

2016-11-21

已发表文章

发表杂志：Scientific Reports

发表类型: Original Contributions

影响因子(IF): 4.379

PMID: 27869211 Pubmed原文链接 全文下载

主要研究背景及目的

Little is known about the association between homocysteine (Hcy) and asymptomatic CAS in the healthy population. The purpose of this study was to investigate the relationship between Hcy levels andasymptomatic CAS in a Chinese community population.

方法

The current study included 5393 participants who were age of 40 years or older, and free of stroke, transient ischemic attack, and coronary artery disease. Demographic and clinical variables were investigated, and the presence of CAS was assessed by Color Doppler Ultrasound. A multivariate logistic regression was used to examine the association between Hcy levels and asymptomatic CAS.

结论

In this large-population, community-based study, Hcy is an independent indicator of asymptomatic CAS, especially in patients with diabetes.

主要结果

361 (6.69%) participants were diagnosed with asymptomatic CAS, who had higher Hcy levels compared with those without (p-value for trend = 0.0001). After adjusting other possible risk factors, Hcy > 19.3μmol/L was considered as an independent indicator of asymptomatic CAS (OR 1.53, 95%CI 1.05-2.23; p-value for trend = 0.0265), but with a difference between participants with diabetes and without [OR (95%CI): 2.89(1.02-8.22) vs. 1.42(0.95-2.12); P interaction < 0.05].