Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Association between Carotid Plaque and Cognitive Impairment in Chinese Stroke Population: The SOS-Stroke Study
First author：Anxin Wang
Corresponding author：Yongjun Wang,Yilong Wang
essential_information
- Person in charge：Anxin Wang
- Data Sources： OTHERS
- Number of papers：OTHERS20190081
- Published time：2017-06-08
2017-06-08
Published articles
Journal：Scientific Reports
Publication type: Original Contributions
IF(IF): 4.379
PMID: 28596524 Link To Pubmed Full text Download
Background And Purpose
We aimed to investigate the association between carotid plaques and cognitive impairment among patients with acute ischemic stroke, and to assess key clinical implications.
Method
In the Acute Ischemic Stroke Study, patients who received a cognitive testing and underwent complete carotid artery ultrasound scans were included. Cognitive function was measured by the mini-mental state examination. The cross-sectional relationships between cognitive impairment and carotid plaques were evaluated using multivariate logistic regression analysis.
Conclusion
In this acute ischemic stroke population, the number of carotid plaques, the number of carotid arteries with plaque and plaque stability are all associated with cognitive impairment.
Main results
Of the 3116 patients included in this study, 826 (26.51%) patients were diagnosed with cognitive impairment. After adjusting for potential confounders, patients with ≥2 carotid plaques (odds ratio [OR] = 1.47; 95% confidence interval [CI]: 1.19–1.82), patients with ≥2 number of carotid arteries with plaque (OR = 1.48; 95% CI: 1.19–1.84) and patients with hypoechoic plaque (OR = 2.05; 95% CI: 1.24–3.38) are more likely to have cognitive impairment.