国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Association between Carotid Plaque and Cognitive Impairment in Chinese Stroke Population: The SOS-Stroke Study

第一作者：Anxin Wang

通讯作者：Yongjun Wang,Yilong Wang

Carotid Plaque Cognitive Impairment Chinese Stroke

基本信息

  • 负责人：Anxin Wang
  • 数据来源： OTHERS
  • 论文编号：OTHERS20190081
  • 发表时间：2017-06-08

2017-06-08

已发表文章

发表杂志：Scientific Reports

发表类型: Original Contributions

影响因子(IF): 4.379

PMID: 28596524 Pubmed原文链接 全文下载

主要研究背景及目的

We aimed to investigate the association between carotid plaques and cognitive impairment among patients with acute ischemic stroke, and to assess key clinical implications.

方法

In the Acute Ischemic Stroke Study, patients who received a cognitive testing and underwent complete carotid artery ultrasound scans were included. Cognitive function was measured by the mini-mental state examination. The cross-sectional relationships between cognitive impairment and carotid plaques were evaluated using multivariate logistic regression analysis.

结论

In this acute ischemic stroke population, the number of carotid plaques, the number of carotid arteries with plaque and plaque stability are all associated with cognitive impairment.

主要结果

Of the 3116 patients included in this study, 826 (26.51%) patients were diagnosed with cognitive impairment. After adjusting for potential confounders, patients with ≥2 carotid plaques (odds ratio [OR] = 1.47; 95% confidence interval [CI]: 1.19–1.82), patients with ≥2 number of carotid arteries with plaque (OR = 1.48; 95% CI: 1.19–1.84) and patients with hypoechoic plaque (OR = 2.05; 95% CI: 1.24–3.38) are more likely to have cognitive impairment.