Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Hypertriglyceridemic waist phenotype and risk of cardiovascular diseases in China: Results from the Kailuan Study
First author：AnxinWang,Zhaoxia Li
Corresponding author：Xiuhua Guo,Shouling Wu,Xingquan Zhao
essential_information
- Person in charge：AnxinWang,Zhaoxia Li
- Data Sources： Kailuan Study
- Number of papers：KAILUAN STUDY20190087
- Published time：2014-04-06
2014-04-06
Published articles
Journal：International Journal of Cardiology
Publication type: Original Contributions
IF(IF): 4.164
PMID: 24745860 Link To Pubmed Full text Download
Background And Purpose
Background: While some case–control studies have showed the correlation between the hypertriglyceridemic waist (HTGW) phenotype (increased WC and hypertriglyceridemia) and cardiovascular disease (CVD) events, there are few data regarding this correlation in cohort studies, especially in Asian populations that have a higher prevalence of central obesity than other populations. Objective: The aim of this study was to explore the relationship between HTGW phenotype and risk of incident CVD events among men and women in China.
Method
We analyzed 95,015 participants (18–98 years old) in the Kailuan Study. CVDs developed in 1958 people during follow-up. The cutoffs for defining HTGW phenotype were a waist circumference (WC) of 90 cm or more and a triglyceride level of 2.0 mmol/L or more for men and a WC of 85 cm or more and a triglyceride level of 1.5 mmol/L or more forwomen. Hazard ratios (HRs) with 95% confidence intervals (CIs)were calculated from Cox regression models.
Conclusion
HTGW phenotype was associated with the risk of CVDs independently. HTGW phenotype might be a simple but useful tool to screen the individuals at a high risk for future CVDs, and it might be recommended in most clinical practices.
Main results
Compared with participants who had a normalWC and a normal triglyceride level (NWNT), those with HTGW phenotype had a higher WC, body mass index, prevalence of hypertension and diabetes mellitus; and a lower level of high-density lipoprotein cholesterol. The HTGW group had an unadjusted HR of 1.76 (95% CI = 1.55–1.99) for future CVDs compared with the NWNT group. After adjustment for confounders, the HR still remained significant (HR = 1.24, 95% CI = 1.07–1.44).