国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Hypertriglyceridemic waist phenotype and risk of cardiovascular diseases in China: Results from the Kailuan Study

第一作者：AnxinWang,Zhaoxia Li

通讯作者：Xiuhua Guo,Shouling Wu,Xingquan Zhao

Waist circumference Triglycerides Hypertriglycerid

基本信息

2014-04-06

已发表文章

发表杂志：International Journal of Cardiology

发表类型: Original Contributions

影响因子(IF): 4.164

PMID: 24745860 Pubmed原文链接 全文下载

主要研究背景及目的

Background: While some case–control studies have showed the correlation between the hypertriglyceridemic waist (HTGW) phenotype (increased WC and hypertriglyceridemia) and cardiovascular disease (CVD) events, there are few data regarding this correlation in cohort studies, especially in Asian populations that have a higher prevalence of central obesity than other populations. Objective: The aim of this study was to explore the relationship between HTGW phenotype and risk of incident CVD events among men and women in China.

方法

We analyzed 95,015 participants (18–98 years old) in the Kailuan Study. CVDs developed in 1958 people during follow-up. The cutoffs for defining HTGW phenotype were a waist circumference (WC) of 90 cm or more and a triglyceride level of 2.0 mmol/L or more for men and a WC of 85 cm or more and a triglyceride level of 1.5 mmol/L or more forwomen. Hazard ratios (HRs) with 95% confidence intervals (CIs)were calculated from Cox regression models.

结论

HTGW phenotype was associated with the risk of CVDs independently. HTGW phenotype might be a simple but useful tool to screen the individuals at a high risk for future CVDs, and it might be recommended in most clinical practices.

主要结果

Compared with participants who had a normalWC and a normal triglyceride level (NWNT), those with HTGW phenotype had a higher WC, body mass index, prevalence of hypertension and diabetes mellitus; and a lower level of high-density lipoprotein cholesterol. The HTGW group had an unadjusted HR of 1.76 (95% CI = 1.55–1.99) for future CVDs compared with the NWNT group. After adjustment for confounders, the HR still remained significant (HR = 1.24, 95% CI = 1.07–1.44).