Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The Relationship between Cerebral White Matter Integrity and Cognitive Function in Mild Stroke with Basal Ganglia Region Infarcts
First author：Lijun Zuo,Zixiao LI
Corresponding author：Yongjun Wang
essential_information
- Person in charge：Lijun Zuo,Zixiao LI
- Data Sources： OTHERS
- Number of papers：OTHERS20190172
- Published time：2018-05-30
2018-05-30
Published articles
Journal：Scientific reports
Publication type: Special Reports
IF(IF): 4.379
PMID: 29849078 Link To Pubmed Full text Download
Background And Purpose
Mild stroke is a known risk factor for dementia. The relationship between cerebral white matter (WM) integrity and cognitive impairment (CI) in mild stroke patients with basal ganglia region infarcts is unknown.
Method
Statistical analyses were performed with SPSS Statistics 20.0 (IBM Corporation, New York, USA). Demographic information (age, sex, education, history of hypertension, impaired glucose regulation, hyperlipidemia, hyperhomocysteinemia, peripheral arterial disease, alcohol intake and cigarette smoking habits, family history of stroke) and clinical evaluation (the scores of mRS, HAMD, IQCODE, Instrumental and Basic ADL, the diameter, locations and affected circulation systems of lesions) was compared among the control group, the NCI group and the CI group.
Conclusion
The majority of stroke patients were in their 50s (56.90 ± 9.23 years). CI patients exhibited a significantly decreased Z score in visual delayed memory and remarkably decreased FA values in the right external capsule and right fornix (FWE-corrected) compared with NCI patients and controls.
Main results
Demographics and clinical profile: (1)There were no significant differences in age, sex, education, the scores of NIHSS at admission, mRS, HAMD, basal ADL, IQCODE, the prevalence of risk factors, family history and affected circulation system among the three groups. (2)There were no remarkable differences in diameter of lesions between the NCI and CI groups. (3)There were no significant differences in number of patients with multiple or multi-site infarcts between the NCI group and the CI group.