国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

The Relationship between Cerebral White Matter Integrity and Cognitive Function in Mild Stroke with Basal Ganglia Region Infarcts

第一作者：Lijun Zuo,Zixiao LI

通讯作者：Yongjun Wang

Mild stroke cerebral white matter (WM) integrity a

基本信息

2018-05-30

已发表文章

发表杂志：Scientific reports

发表类型: Special Reports

影响因子(IF): 4.379

PMID: 29849078 Pubmed原文链接 全文下载

主要研究背景及目的

Mild stroke is a known risk factor for dementia. The relationship between cerebral white matter (WM) integrity and cognitive impairment (CI) in mild stroke patients with basal ganglia region infarcts is unknown.

方法

Statistical analyses were performed with SPSS Statistics 20.0 (IBM Corporation, New York, USA). Demographic information (age, sex, education, history of hypertension, impaired glucose regulation, hyperlipidemia, hyperhomocysteinemia, peripheral arterial disease, alcohol intake and cigarette smoking habits, family history of stroke) and clinical evaluation (the scores of mRS, HAMD, IQCODE, Instrumental and Basic ADL, the diameter, locations and affected circulation systems of lesions) was compared among the control group, the NCI group and the CI group.

结论

The majority of stroke patients were in their 50s (56.90 ± 9.23 years). CI patients exhibited a significantly decreased Z score in visual delayed memory and remarkably decreased FA values in the right external capsule and right fornix (FWE-corrected) compared with NCI patients and controls.

主要结果

Demographics and clinical profile: (1)There were no significant differences in age, sex, education, the scores of NIHSS at admission, mRS, HAMD, basal ADL, IQCODE, the prevalence of risk factors, family history and affected circulation system among the three groups. (2)There were no remarkable differences in diameter of lesions between the NCI and CI groups. (3)There were no significant differences in number of patients with multiple or multi-site infarcts between the NCI group and the CI group.