Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Heterogeneity among patients with Parkinson's disease: Cluster analysis and genetic association
First author：Lingyan Ma
Corresponding author：Tao Feng
essential_information
- Person in charge：Lingyan Ma
- Data Sources： OTHERS
- Number of papers：OTHERS20190332
- Published time：2015-02-21
2015-02-21
Published articles
Journal：Journal of the Neurological Sciences
Publication type: Original Article
IF(IF): 3.181
PMID: 25732803 Link To Pubmed Full text Download
Background And Purpose
Method
A k-means CA of demographics, disease progression, motor and non-motor symptoms was performed from 1,510 Chinese PD patients from the Chinese National Consortium on Neurodegenerative Diseases. Pearson correlation analysis was performed to eliminate uninformative characteristics. Blood samples from 852 patients were obtained for genetic analysis of LRRK2 and GBA. Genotypic associations between various subtypes and genetic variants were examined using chi-square test.
Conclusion
No associations were identified between polymorphisms in LRRK2 (R1628P) and GBA (L444P) genes and the four subtypes (P>0.05).
Main results
We identified four different subtypes: subtype 1 was non-tremor dominant (NTD, n=469; 31.1%); subtype 2 had a rapid disease progression with late onset (RDP-LO, n=67; 4.4%); subtype 3 had benign pure motor characteristics (BPM, n=778; 51.5%) without non-motor disturbances; and subtype 4 was tremor dominant with slow disease progression (TD-SP, n=196; 13.0%). Subtypes 1, 2, and 4 had similar mean age of onset.