国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Heterogeneity among patients with Parkinson's disease: Cluster analysis and genetic association
第一作者：Lingyan Ma
通讯作者：Tao Feng
基本信息
- 负责人：Lingyan Ma
- 数据来源： OTHERS
- 论文编号：OTHERS20190332
- 发表时间：2015-02-21
2015-02-21
已发表文章
发表杂志：Journal of the Neurological Sciences
发表类型: Original Article
影响因子(IF): 3.181
PMID: 25732803 Pubmed原文链接 全文下载
主要研究背景及目的
方法
A k-means CA of demographics, disease progression, motor and non-motor symptoms was performed from 1,510 Chinese PD patients from the Chinese National Consortium on Neurodegenerative Diseases. Pearson correlation analysis was performed to eliminate uninformative characteristics. Blood samples from 852 patients were obtained for genetic analysis of LRRK2 and GBA. Genotypic associations between various subtypes and genetic variants were examined using chi-square test.
结论
No associations were identified between polymorphisms in LRRK2 (R1628P) and GBA (L444P) genes and the four subtypes (P>0.05).
主要结果
We identified four different subtypes: subtype 1 was non-tremor dominant (NTD, n=469; 31.1%); subtype 2 had a rapid disease progression with late onset (RDP-LO, n=67; 4.4%); subtype 3 had benign pure motor characteristics (BPM, n=778; 51.5%) without non-motor disturbances; and subtype 4 was tremor dominant with slow disease progression (TD-SP, n=196; 13.0%). Subtypes 1, 2, and 4 had similar mean age of onset.