Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
Integrative proteomics and transcriptomics revealed that activation of the IL-6R/JAK2/STAT3/MMP9 signaling pathway is correlated with invasion of pituitary null cell adenomas.
First author：Jie Feng, Sheng-Yuan Yu
Corresponding author：Ya-Zhuo Zhang
essential_information
- Person in charge：Jie Feng, Sheng-Yuan Yu
- Data Sources： OTHERS
- Number of papers：OTHERS20190391
- Published time：2016-11-15
2016-11-15
Published articles
Journal：Mol Cell Endocrinol
Publication type: Research Article
IF(IF): 4.102
PMID: 27465831 Link To Pubmed Full text Download
Background And Purpose
Method
Total ribonucleic acid (RNA) extraction Microarray hybridization Protein preparation and nanoLC-MS/MS analysis Reverse transcription and quantitative real-time polymerase chain reaction (qRT-PCR) analysis Immunohistochemical staining Bioinformatics analysis and statistics
Conclusion
Our data suggest that overactivation of the IL-6R/JAK2/STAT3/MMP9 pathway is critical for the invasion of PNCAs.