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Resveratrol sensitizes glioblastoma-initiating cells to temozolomide by inducing cell apoptosis and promoting differentiation.
First author：Hao Li
Corresponding author：Ye Li, Yong Cao
essential_information
2016-01-01
Published articles
Journal：Oncol Rep
Publication type: Research Article
IF(IF): 3.906
PMID: 26498391 Link To Pubmed Full text Download
Background And Purpose
Method
GIC culture and cell immunofluorescence. Limiting dilution assay. Determination of GICs in NOD/SCID mice. Cell viability, apoptosis and sphere counting assay. Measurement of caspase-3 activity. DNA double-strand break (DSB) assay. Western blot analysis. In vivo xenograft study and immunohistochemical study
Conclusion
Our results propose that temozolomide and resveratrol combination strategy may be effective in the management of glioblastoma patients, particularly for those patients who have been present with a high abundance of glioblastoma-initiating cells in their tumors and show slight responsiveness to temozolomide.