国家神经系统疾病临床医学研究中心数据管理与共享系统

Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases

《国家中心数据管理与共享系统操作说明书 —— 研究者部分》

Resveratrol sensitizes glioblastoma-initiating cells to temozolomide by inducing cell apoptosis and promoting differentiation.

第一作者：Hao Li

通讯作者：Ye Li, Yong Cao

glioblastoma-initiating cells resveratrol temozo

基本信息

  • 负责人：Hao Li
  • 数据来源： OTHERS
  • 论文编号：OTHERS20190409
  • 发表时间：2016-01-01

2016-01-01

已发表文章

发表杂志：Oncol Rep

发表类型: Research Article

影响因子(IF): 3.906

PMID: 26498391 Pubmed原文链接 全文下载

主要研究背景及目的

方法

GIC culture and cell immunofluorescence. Limiting dilution assay. Determination of GICs in NOD/SCID mice. Cell viability, apoptosis and sphere counting assay. Measurement of caspase-3 activity. DNA double-strand break (DSB) assay. Western blot analysis. In vivo xenograft study and immunohistochemical study

结论

Our results propose that temozolomide and resveratrol combination strategy may be effective in the management of glioblastoma patients, particularly for those patients who have been present with a high abundance of glioblastoma-initiating cells in their tumors and show slight responsiveness to temozolomide.

主要结果