Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The correlation between white matter hyperintensity and balance disorder and fall risk: An observational, prospective cohort study.
First author：Dongchao Shen
Corresponding author：Chunxue Wang
essential_information
- Person in charge：Dongchao Shen
- Data Sources： OTHERS
- Number of papers：OTHERS20190467
- Published time：2016-12-15
2016-12-15
Published articles
Journal：Chronic Dis Transl Med
Publication type: Research Article
IF(IF): 0
PMID: 29063039 Link To Pubmed Full text Download
Background And Purpose
Method
In a representative sample of hospital-based individuals aged 50 years and older in China, the patients' history of falls, magnetic resonance imaging data, scores on the 9-item Berg Balance Scale (BBS-9) test and timed up-and-go test (TUGT), and sensorimotor measures of computerized dynamic posturography (CDP) were analyzed. Incident falls were recorded prospectively over a 12-month period. Using regression modeling, the association between the risk of falls and baseline WMH was estimated.
Conclusion
Although WMH was associated with an increased risk of falls, it was not an independent predictor.
Main results
Only individuals with severe WMH were at an increased risk of falls, and CDP was more sensitive than BBS-9 in detecting WMH-related balance and gait dysfunction. However, WMH was not an independent predictor of falls. Taller height and overweight or obese body habitus were identified as novel protective factors for falls. Female, fall history, and increased TUGT score were identified as independent risk factors for falls in older Chinese people.