国家神经系统疾病临床医学研究中心数据管理与共享系统
Data Management And Sharing System of China National Clinical Research Center for Neurological Diseases
The correlation between white matter hyperintensity and balance disorder and fall risk: An observational, prospective cohort study.
第一作者：Dongchao Shen
通讯作者：Chunxue Wang
基本信息
- 负责人：Dongchao Shen
- 数据来源： OTHERS
- 论文编号：OTHERS20190467
- 发表时间：2016-12-15
2016-12-15
已发表文章
主要研究背景及目的
方法
In a representative sample of hospital-based individuals aged 50 years and older in China, the patients' history of falls, magnetic resonance imaging data, scores on the 9-item Berg Balance Scale (BBS-9) test and timed up-and-go test (TUGT), and sensorimotor measures of computerized dynamic posturography (CDP) were analyzed. Incident falls were recorded prospectively over a 12-month period. Using regression modeling, the association between the risk of falls and baseline WMH was estimated.
结论
Although WMH was associated with an increased risk of falls, it was not an independent predictor.
主要结果
Only individuals with severe WMH were at an increased risk of falls, and CDP was more sensitive than BBS-9 in detecting WMH-related balance and gait dysfunction. However, WMH was not an independent predictor of falls. Taller height and overweight or obese body habitus were identified as novel protective factors for falls. Female, fall history, and increased TUGT score were identified as independent risk factors for falls in older Chinese people.